Did you know...
that FrontalCortex.com has software for your PalmOs handheld?

Myelin 06

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.


Courtesy of Dr. Mark Cohen
Along with Canavan disease, this metabolic disorder may be distinguished clinically from other leukodystrophies based on which of the following features?

 
        A) Mutations in astrocyte specific proteins
 
        B) Vacuolation of white matter
 
        C) Presence of metabolic astrocytosis
 
        D) Megalencephaly in early stages of disease
 
        E) Peripheral neuropathy
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average user rating for this question = 4.5 = How users like you have rated this question.
This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Mutations in astrocyte specific proteins

This answer is incorrect.


True of Alexander disease (GFAP) but not Canavan disease (aspartoacylase deficiency)  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) Vacuolation of white matter

This answer is incorrect.


Characteristic of Canavan disease, not part of Alexander disease  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) Presence of metabolic astrocytosis

This answer is incorrect.


Both Alzheimer type I and II astrocytes may be seen in Canavan disease, but are not part of Alexander disease  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) Megalencephaly in early stages of disease

This answer is correct.


Megalencephaly is seen early in the course of Canavan and Alexander disease.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) Peripheral neuropathy

This answer is incorrect.


Peripheral neuropathy is not seen in either Alexander or Canavan disease  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4.5
Please log in if you want to rate questions.

 

 

 

 

References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)Advertising:
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 4.5
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
pathology
Myelin 06
Question ID: 021509099
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120

User Comments About This Question:

0 user entries
Please log in if you'd like to add a comment.