Myelin 08

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.

 
        A) Tumefactive demyelination
 
        B) Radiation leukoencephalopathy
 
        C) Panencephalitic Jakob-Creutzfeldt disease
 
        D) Ataxia-Telangiectasia
 
        E) Mitochondrial Eencephalopathy with Lactic Acidosis and Stroke-like syndrome
 

 

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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Tumefactive demyelination

This answer is correct.

Creutzfeldt, or Creutzfeldt-Peters, cells are characteristically seen in tumor like demyelinating lesions  (See References)

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B) Radiation leukoencephalopathy

This answer is incorrect.

Enlarged astrocytes with hyperchromatic polyploid nuclei may be seen with radiation injury as a result of inability to successfully replicate DNA  (See References)

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C) Panencephalitic Jakob-Creutzfeldt disease

This answer is incorrect.

Though Creutzfeldt is credited with both the cell & the disease, they are not otherwise related  (See References)

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D) Ataxia-Telangiectasia

This answer is incorrect.

Also characterized by polyploid nuclei in a variety of cell types, nuclear morphology resembling these Creutzfeldt cells is not seen in A-T.  (See References)

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E) Mitochondrial Eencephalopathy with Lactic Acidosis and Stroke-like syndrome

This answer is incorrect.

MELAS may show spongioform changes within white matter, but does not show abnormal cellular morphology within white matter lesions  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Myelin 08
Question ID: 021509112
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120