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Myelin 08

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.

Though not pathognomonic, this cell is characteristically seen in which of the following processes?

 
        A) Tumefactive demyelination
 
        B) Mitochondrial Eencephalopathy with Lactic Acidosis and Stroke-like syndrome
 
        C) Ataxia-Telangiectasia
 
        D) Radiation leukoencephalopathy
 
        E) Panencephalitic Jakob-Creutzfeldt disease
 

 


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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Tumefactive demyelination

This answer is correct.


Creutzfeldt, or Creutzfeldt-Peters, cells are characteristically seen in tumor like demyelinating lesions  (See References)

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B) Mitochondrial Eencephalopathy with Lactic Acidosis and Stroke-like syndrome

This answer is incorrect.


MELAS may show spongioform changes within white matter, but does not show abnormal cellular morphology within white matter lesions  (See References)

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C) Ataxia-Telangiectasia

This answer is incorrect.


Also characterized by polyploid nuclei in a variety of cell types, nuclear morphology resembling these Creutzfeldt cells is not seen in A-T.  (See References)

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D) Radiation leukoencephalopathy

This answer is incorrect.


Enlarged astrocytes with hyperchromatic polyploid nuclei may be seen with radiation injury as a result of inability to successfully replicate DNA  (See References)

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E) Panencephalitic Jakob-Creutzfeldt disease

This answer is incorrect.


Though Creutzfeldt is credited with both the cell & the disease, they are not otherwise related  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)Advertising:
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pathology
Myelin 08
Question ID: 021509112
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120

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