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Neurodegen 08

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Friday, February 20 2009.


Courtesy of Dr. Mark Cohen
The abnormalities present in this coronal section are most consistent with which of the following diseases?

 
        A) Progressive supranuclear palsy
 
        B) Parkinson disease
 
        C) Huntington disease
 
        D) Corticobasal degeneration
 
        E) Multiple system atrophy
 

 


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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 20, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Progressive supranuclear palsy

This answer is incorrect.


Would show subthalamic and, in severe cases, pallidal atrophy   (See References)

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B) Parkinson disease

This answer is incorrect.


Generally shows no visible atrophy within basal ganglia   (See References)

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C) Huntington disease

This answer is incorrect.


Expect caudate atrophy in addition to putaminal atrophy   (See References)

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D) Corticobasal degeneration

This answer is incorrect.


Would show unilateral cortical atrophy and, in severe cases, pallidal atrophy   (See References)

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E) Multiple system atrophy

This answer is correct.


Bilateral putaminal degeneration is typically seen in striatonigral degeneration   (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820) Advertising:
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pathology
Neurodegen 08
Question ID: 021609187
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/20/2009
Estimated Permutations: 120

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