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Pathology in Alzheimer dementia 01

Topic: Pathology

Created on Saturday, April 28 2007 by jdmiles

Last modified on Saturday, April 28 2007.


Courtesy of National Institute of Aging

This pathology slide was obtained from an adult patient.

Which of the following statements about this image is true?


 
        A) This image shows a neurofibrillary tangle
 
        B) The pathologic finding in this image is intracellular
 
        C) This pathology is pathognomonic for Alzheimer disease
 
        D) The pathologic finding in this image is an accumulation of Tau protein
 
        E) This image shows an amyloid plaque
 

 


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This question was created on April 28, 2007 by jdmiles.
This question was last modified on April 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) this image shows a neurofibrillary tangle

This answer is incorrect.


The slide shows an amyloid plaque (a.k.a. "senile plaque"), not a neurofibrillary tangle.  (See References)

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B) the pathologic finding in this image is intracellular

This answer is incorrect.


The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques are extracellular accumulations of beta amyloid protein. Neurofibrillary tangles are intracellular.  (See References)

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C) this pathology is pathognomonic for Alzheimer disease

This answer is incorrect.


The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques, while associated with Alzheimer disease and other dementing processes, are also seen in the brains of adults with mild cognitive impairment, and in cognitively normal adults.  (See References)

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D) the pathologic finding in this image is an accumulation of Tau protein

This answer is incorrect.


The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques are extracellular accumulations of beta amyloid protein. Tau protein is associated with neurofibrillary tangles.  (See References)

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E) this image shows an amyloid plaque

This answer is correct.


The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques, while associated with Alzheimer disease and other dementing processes, are also seen in the brains of adults with mild cognitive impairment, and in cognitively normal adults.  (See References)

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References:

1. Morris, J.C., Storandt, M., McKeel, D.W., Rubin, E.H., Price, J.L., Grant, E.A., and Berg, L. (1996). "Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease." Neurology, 46(3) 707-19. (PMID:8618671)
2. Schmitt, F.A., Davis, D.G., Wekstein, D.R., Smith, C.D., Ashford, J.W., and Markesbery, W.R. (2000). ""Preclinical" AD revisited: neuropathology of cognitively normal older adults." Neurology, 55(3) 370-6. (PMID:10932270)
3. Bennett, D.A., Schneider, J.A., Arvanitakis, Z., Kelly, J.F., Aggarwal, N.T., Shah, R.C., and Wilson, R.S. (2006). "Neuropathology of older persons without cognitive impairment from two community-based studies." Neurology, 66(12) 1837-44. (PMID:16801647)
4. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia.
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pathology
Pathology in Alzheimer dementia 01
Question ID: 042807088
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 04/28/2007
Modified: 04/28/2007
Estimated Permutations: 3000

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