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Basic Neuropathology 05

Topic: Pathology

Created on Saturday, December 8 2007 by jdmiles

Last modified on Saturday, December 8 2007.

This is a photomicrograph of a brain biopsy stained with H&E. What is the abnormal finding in this slide?

 
        A) Granulomatous disease
 
        B) Rosenthal fibers
 
        C) Necrosis and pseudopallisading
 
        D) Inflammatory demyelination
 
        E) This is normal cortex
 

 


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This question was created on December 08, 2007 by jdmiles.
This question was last modified on December 08, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Granulomatous disease

This answer is incorrect.


The abnormalities we are looking at in this slide are pseudopallisading and necrosis. "Pallisading" is when cells line up next to each other, like slats in a picket fence. These cells appear to pallisade around the central pale area, which represents necrotic tissue. Pseudopallisading and necrosis are findings associated with glioblastoma multiforma (GBM), which is the tumor shown in this slide.  (See References)

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B) Rosenthal fibers

This answer is incorrect.


The abnormalities we are looking at in this slide are pseudopallisading and necrosis. "Pallisading" is when cells line up next to each other, like slats in a picket fence. These cells appear to pallisade around the central pale area, which represents necrotic tissue. Pseudopallisading and necrosis are findings associated with glioblastoma multiforma (GBM), which is the tumor shown in this slide.  (See References)

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C) Necrosis and pseudopallisading

This answer is correct.


The abnormalities we are looking at in this slide are pseudopallisading and necrosis. "Pallisading" is when cells line up next to each other, like slats in a picket fence. These cells appear to pallisade around the central pale area, which represents necrotic tissue. Pseudopallisading and necrosis are findings associated with glioblastoma multiforma (GBM), which is the tumor shown in this slide.  (See References)

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D) Inflammatory demyelination

This answer is incorrect.


The abnormalities we are looking at in this slide are pseudopallisading and necrosis. "Pallisading" is when cells line up next to each other, like slats in a picket fence. These cells appear to pallisade around the central pale area, which represents necrotic tissue. Pseudopallisading and necrosis are findings associated with glioblastoma multiforma (GBM), which is the tumor shown in this slide.  (See References)

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E) This is normal cortex

This answer is incorrect.


The abnormalities we are looking at in this slide are pseudopallisading and necrosis. "Pallisading" is when cells line up next to each other, like slats in a picket fence. These cells appear to pallisade around the central pale area, which represents necrotic tissue. Pseudopallisading and necrosis are findings associated with glioblastoma multiforma (GBM), which is the tumor shown in this slide.  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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pathology
Basic Neuropathology 05
Question ID: 120807148
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/08/2007
Modified: 12/08/2007
Estimated Permutations: 60480

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