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Muscle Fiber Histology 01

Topic: Pathology

Created on Thursday, December 20 2007 by jdmiles

Last modified on Thursday, December 20 2007.

This photomicrograph shows a cytochrome C oxidase stain of skeletal muscle. In this type of stain:

 
        A) Type 2 fibers normally stain darker than type 1 fibers
 
        B) Muscle fibers affected by Duchenne muscular dystrophy appear darker
 
        C) Muscle fibers affected by Becker muscular dystrophy appear darker
 
        D) Type 1 fibers normally stain darker than type 2 fibers
 
        E) Denervated muscle fibers appear darker
 

 


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This question was created on December 20, 2007 by jdmiles.
This question was last modified on December 20, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) type 2 fibers normally stain darker than type 1 fibers

This answer is incorrect.


Cytochrome C oxidase is a marker of mitochondrial activity. Type 1 muscle fibers have a higher capacity for oxidative metabolism than type 2 cells, which have a higher capacity for anaerobic metabolism. This means that the type 1 muscle cells will stain darker.  (See References)

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B) muscle fibers affected by Duchenne muscular dystrophy appear darker

This answer is incorrect.


Cytochrome C oxidase is a marker of mitochondrial activity. Type 1 muscle fibers have a higher capacity for oxidative metabolism than type 2 cells, which have a higher capacity for anaerobic metabolism. This means that the type 1 muscle cells will stain darker.  (See References)

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C) muscle fibers affected by Becker muscular dystrophy appear darker

This answer is incorrect.


Cytochrome C oxidase is a marker of mitochondrial activity. Type 1 muscle fibers have a higher capacity for oxidative metabolism than type 2 cells, which have a higher capacity for anaerobic metabolism. This means that the type 1 muscle cells will stain darker.  (See References)

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D) type 1 fibers normally stain darker than type 2 fibers

This answer is correct.


Cytochrome C oxidase is a marker of mitochondrial activity. Type 1 muscle fibers have a higher capacity for oxidative metabolism than type 2 cells, which have a higher capacity for anaerobic metabolism. This means that the type 1 muscle cells will stain darker.  (See References)

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E) denervated muscle fibers appear darker

This answer is incorrect.


Cytochrome C oxidase is a marker of mitochondrial activity. Type 1 muscle fibers have a higher capacity for oxidative metabolism than type 2 cells, which have a higher capacity for anaerobic metabolism. This means that the type 1 muscle cells will stain darker.  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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pathology
Muscle Fiber Histology 01
Question ID: 122007034
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/20/2007
Modified: 12/20/2007
Estimated Permutations: 8400

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