antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Phenobarbital is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 
        B) Tiagabine is indicated for treatment of partial seizures.
 
        C) Levetiracetam is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 
        D) Valproic acid is approved as adjunct therapy only.
 
        E) Primidone can be given as a loading dose.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Phenobarbital is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.

The statement, "Phenobarbital is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Phenobarbital causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is excreted in breast milk, and can be given as a loading dose.  (See References)

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B) Tiagabine is indicated for treatment of partial seizures.

This answer is correct.

The statement, "Tiagabine is indicated for treatment of partial seizures." is true.
Tiagabine causes reduction of sodium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, and is approved as adjunct therapy only.  (See References)

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C) Levetiracetam is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.

The statement, "Levetiracetam is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Levetiracetam works via an unknown mechanism, is indicated for treatment of partial seizures, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, has no known significant drug interactions, and has no known significant interactions with other AEDs.  (See References)

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D) Valproic acid is approved as adjunct therapy only.

This answer is incorrect.

The statement, "Valproic acid is approved as adjunct therapy only." is false.
Valproic acid causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatement of complex partial seizures, is indicated for tonic-clonic, is indicated for treatment of absence seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, and is excreted in breast milk.  (See References)

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E) Primidone can be given as a loading dose.

This answer is incorrect.

The statement, "Primidone can be given as a loading dose." is false.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0