antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Zonisamide is metabolized primarily in the liver.
 
        B) Levetiracetam induces hepatic enzymes.
 
        C) Carbamazepine is indicated for treatment of absence seizures.
 
        D) Primidone is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 
        E) Topiramate is approved as adjunct therapy only.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Zonisamide is metabolized primarily in the liver.

This answer is correct.

The statement, "Zonisamide is metabolized primarily in the liver." is true.
Zonisamide causes reduction of sodium currents, causes reduction of T-Calcium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, is approved as adjunct therapy only, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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B) Levetiracetam induces hepatic enzymes.

This answer is incorrect.

The statement, "Levetiracetam induces hepatic enzymes." is false.
Levetiracetam works via an unknown mechanism, is indicated for treatment of partial seizures, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, has no known significant drug interactions, and has no known significant interactions with other AEDs.  (See References)

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C) Carbamazepine is indicated for treatment of absence seizures.

This answer is incorrect.

The statement, "Carbamazepine is indicated for treatment of absence seizures." is false.
Carbamazepine causes reduction of sodium currents, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, is excreted in breast milk, must be started at a low dose, may exacerbate absence seizures, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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D) Primidone is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.

The statement, "Primidone is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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E) Topiramate is approved as adjunct therapy only.

This answer is incorrect.

The statement, "Topiramate is approved as adjunct therapy only." is false.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0