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Antiepileptic Medications 05

Topic: Pharmacology

Created on Friday, September 28 2007 by jdmiles

Last modified on Friday, September 28 2007.

A 3 year-old boy presents to your clinic for evaluation.  He is developmentally delayed, and has had seizures for the past 2 years.  Seizure types include generalized tonic-clinic, atonic, tonic, and absence.  EEG shows 2 1/2 Hz spike and wave complexes while the child is wake, and 10 Hz rhythmic bursts while he is asleep.

Of the following treatments, which is most likely to have a beneficial effect in the treatment of this boy's seizures?


 
        A) Clonazepam
 
        B) Gabapentin
 
        C) Fosphenytoin
 
        D) Tiagabine
 
        E) Carbamazepine
 

 


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This question was created on September 28, 2007 by jdmiles.
This question was last modified on September 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Clonazepam

This answer is correct.


Seizures in the Lennox-Gastaut syndrome, which this child has, are often refractory to treatment.  Medications typically used for this condition include valproic acid, clonazepam, lamotrigine, topiramate, and felbamate.  Corticosteroids, ACTH, and the ketogenic diet may also have some benefit.

  (See References)

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B) Gabapentin

This answer is incorrect.


Seizures in the Lennox-Gastaut syndrome, which this child has, are often refractory to treatment.  Medications typically used for this condition include valproic acid, clonazepam, lamotrigine, topiramate, and felbamate.  Corticosteroids, ACTH, and the ketogenic diet may also have some benefit.

  (See References)

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C) Fosphenytoin

This answer is incorrect.


Seizures in the Lennox-Gastaut syndrome, which this child has, are often refractory to treatment.  Medications typically used for this condition include valproic acid, clonazepam, lamotrigine, topiramate, and felbamate.  Corticosteroids, ACTH, and the ketogenic diet may also have some benefit.

  (See References)

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D) Tiagabine

This answer is incorrect.


Seizures in the Lennox-Gastaut syndrome, which this child has, are often refractory to treatment.  Medications typically used for this condition include valproic acid, clonazepam, lamotrigine, topiramate, and felbamate.  Corticosteroids, ACTH, and the ketogenic diet may also have some benefit.

  (See References)

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E) Carbamazepine

This answer is incorrect.


Seizures in the Lennox-Gastaut syndrome, which this child has, are often refractory to treatment.  Medications typically used for this condition include valproic acid, clonazepam, lamotrigine, topiramate, and felbamate.  Corticosteroids, ACTH, and the ketogenic diet may also have some benefit.

  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
2. Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
3. Ilo E. Leppik, . . Handbooks in Health Care Company (ISBN:1931981574)Advertising:
4. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.
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pharmacology
Antiepileptic Medications 05
Question ID: 092807083
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/28/2007
Modified: 09/28/2007
Estimated Permutations: 316800

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