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Agents that Affect Cholinergic Synapses - Super Quiz 01

Topic: Pharmacology

Created on Saturday, October 18 2008 by jdmiles

Last modified on Saturday, October 18 2008.

Which of the following statements is most accurate?

 
        A) Scopolamine irreversibly inhibits acetylcholinesterase
 
        B) Organophosphates are selective nicotinic receptor agonists
 
        C) Scopolamine promotes release of neurotransmitter from the presynaptic neuron
 
        D) Black widow spider venom is a selective muscarinic receptor agonist
 
        E) Pilocarpine is a selective muscarinic receptor agonist
 

 


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This question was created on October 18, 2008 by jdmiles.
This question was last modified on October 18, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) scopolamine irreversibly inhibits acetylcholinesterase

This answer is incorrect.


Scopolamine is a muscarinic receptor antagonist  (See References)

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B) organophosphates are selective nicotinic receptor agonists

This answer is incorrect.


Organophosphates irreversibly inhibit acetylcholinesterase  (See References)

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C) scopolamine promotes release of neurotransmitter from the presynaptic neuron

This answer is incorrect.


Scopolamine is a muscarinic receptor antagonist  (See References)

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D) black widow spider venom is a selective muscarinic receptor agonist

This answer is incorrect.


Black widow spider venom promotes mass release of acetylcholine vesicles  (See References)

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E) pilocarpine is a selective muscarinic receptor agonist

This answer is correct.


Pilocarpine is a selective muscarinic receptor agonist  (See References)

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References:

1. Zygmunt L. Kruk and Christopher J. Pycock. . London ; Chapman and Hall, 1991. (ISBN:412361108)Advertising:
2. Gorio, A., Hurlbut, W.P., and Ceccarelli, B. (1978). "Acetylcholine compartments in mouse diaphragm. Comparison of the effects of black widow spider venom, electrical stimulation, and high concentrations of potassium." J Cell Biol, 78(3) 716-33. (PMID:701357)
3. Salin-Pascual, R.J., and Jimenez-Anguiano, A. (1995). "Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat." Psychopharmacology (Berl), 121(4) 485-7. (PMID:8619013)
4. McCann, C.M., Bracamontes, J., Steinbach, J.H., and Sanes, J.R. (2006). "The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors." Proc Natl Acad Sci U S A, 103(13) 5149-54. (PMID:16549768)
5. Prasarnpun, S., Walsh, J., and Harris, J.B. (2004). "Beta-bungarotoxin-induced depletion of synaptic vesicles at the mammalian neuromuscular junction." Neuropharmacology, 47(2) 304-14. (PMID:15223309)
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pharmacology
Agents that Affect Cholinergic Synapses - Super Quiz 01
Question ID: 10180801
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/18/2008
Modified: 10/18/2008
Estimated Permutations: 41038176000

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