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Norepinephrine 01

Topic: Pharmacology

Created on Saturday, October 18 2008 by jdmiles

Last modified on Saturday, October 18 2008.

From which of the following is norepinephrine synthesized?

 
        A) Serotonin
 
        B) Alanine
 
        C) Leucine
 
        D) Cysteine
 
        E) Tyrosine
 

 


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This question was created on October 18, 2008 by jdmiles.
This question was last modified on October 18, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Serotonin

This answer is incorrect.


Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.  (See References)

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B) Alanine

This answer is incorrect.


Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.  (See References)

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C) Leucine

This answer is incorrect.


Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.  (See References)

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D) Cysteine

This answer is incorrect.


Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.  (See References)

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E) Tyrosine

This answer is correct.


Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.  (See References)

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References:

1. Kandel, E.R., Schwartz, J.H., and Jessel, T.M. (2000). Principles of Neural Science, 4th ed. McGraw-Hill, New York. (ISBN:0838577016) Advertising:
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pharmacology
Norepinephrine 01
Question ID: 101808183
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/18/2008
Modified: 10/18/2008
Estimated Permutations: 3036000

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