Antiepileptic Medications 06

Topic: Pharmacology

Created on Thursday, November 8 2007 by jdmiles

Last modified on Thursday, November 8 2007.

 
        A) Topiramate
 
        B) Phenytoin
 
        C) Oxcarbazepine
 
        D) Valproic acid
 
        E) Carbemazepine
 

 

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This question was created on November 08, 2007 by jdmiles.
This question was last modified on November 08, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) topiramate

This answer is incorrect.

Hyponatremia is a common side effect of oxcarbazepine.

  (See References)

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B) phenytoin

This answer is incorrect.

Hyponatremia is a common side effect of oxcarbazepine.

  (See References)

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C) oxcarbazepine

This answer is correct.

Hyponatremia is a common side effect of oxcarbazepine.

  (See References)

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D) valproic acid

This answer is incorrect.

Hyponatremia is a common side effect of oxcarbazepine.

  (See References)

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---

E) carbemazepine

This answer is incorrect.

Hyponatremia is sometimes seen associated with carbemazepine, but is more common with oxcarbazepine.  (See References)

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References:

1. Dong, X., Leppik, I.E., White, J., and Rarick, J. (2005). "Hyponatremia from oxcarbazepine and carbamazepine." Neurology, 65(12) 1976-8. (PMID:16380624)
2. Nielsen, O.A., Johannessen, A.C., and Bardrum, B. (1988). "Oxcarbazepine-induced hyponatremia, a cross-sectional study." Epilepsy Res, 2(4) 269-71. (PMID:3197696)
3. Pendlebury, S.C., Moses, D.K., and Eadie, M.J. (1989). "Hyponatraemia during oxcarbazepine therapy." Hum Toxicol, 8(5) 337-44. (PMID:2680897)
4. Greenwood, R.S. (2000). "Adverse effects of antiepileptic drugs." Epilepsia, 41 Suppl 2 S42-52. (PMID:10885739)

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pharmacology
Antiepileptic Medications 06
Question ID: 110807194
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 11/08/2007
Modified: 11/08/2007
Estimated Permutations: 59400