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Interactions of AEDs 01

Topic: Pharmacology

Created on Monday, December 24 2007 by jdmiles

Last modified on Monday, December 24 2007.

You have a patient with epilepsy. He is already on one antiepileptic agent, and you are about to add lamotrigine. Which of the following statements about the interactions of lamotrigine and other medications are true?

 
        A) Phenytoin prolongs the half-life of lamotrigine
 
        B) Valproic acid prolongs the half-life of lamotrigine
 
        C) A patient taking both phenytoin and lamotrigine will need a lower dose of lamotrigine than he would if he were not on phenytoin
 
        D) Valproic acid reduces the half-life of lamotrigine
 
        E) A patient taking both sertraline and lamotrigine would need a higher dose of lamotrigine than he would if he were not taking sertraline
 

 


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This question was created on December 24, 2007 by jdmiles.
This question was last modified on December 24, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) phenytoin prolongs the half-life of lamotrigine

This answer is incorrect.


Phenytoin reduces the half-life of lamotrigine. This means that a patient taking both phenytoin and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenytoin.   (See References)

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B) valproic acid prolongs the half-life of lamotrigine

This answer is correct.


Valproic acid prolongs the half-life of lamotrigine. This means that a patient taking both valproic acid and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on valproic acid.   (See References)

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C) A patient taking both phenytoin and lamotrigine will need a lower dose of lamotrigine than he would if he were not on phenytoin

This answer is incorrect.


Phenytoin reduces the half-life of lamotrigine. This means that a patient taking both phenytoin and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenytoin.   (See References)

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D) valproic acid reduces the half-life of lamotrigine

This answer is incorrect.


Valproic acid prolongs the half-life of lamotrigine. This means that a patient taking both valproic acid and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on valproic acid.   (See References)

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E) A patient taking both sertraline and lamotrigine would need a higher dose of lamotrigine than he would if he were not taking sertraline

This answer is incorrect.


Sertraline prolongs the half-life of lamotrigine. This means that a patient taking both sertraline and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on sertraline.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia. (ISBN:0781743524) Advertising:
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pharmacology
Interactions of AEDs 01
Question ID: 122307205
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/24/2007
Modified: 12/24/2007
Estimated Permutations: 252000

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