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the mechanisms of AED action

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Sunday, September 17 2006.

Which of the following is most accurate regarding the mechanisms of AED action?

 
        A) Levetiracetam reduces sodium currents.
 
        B) Tiagabine reduces sodium currents.
 
        C) Carbamazepine reduces T-Calcium currents.
 
        D) Valproic acid acts as a glutamate receptor antagonist.
 
        E) Clonazepam has a mechanism of action which is as yet not known.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 17, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Levetiracetam reduces sodium currents.

This answer is incorrect.


The statement, "Levetiracetam reduces sodium currents." is false.
Levetiracetam has a mechanism of action which is as yet not known.  (See References)

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B) Tiagabine reduces sodium currents.

This answer is correct.


The statement, "Tiagabine reduces sodium currents." is true.
Tiagabine reduces sodium currents.  (See References)

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C) Carbamazepine reduces T-Calcium currents.

This answer is incorrect.


The statement, "Carbamazepine reduces T-Calcium currents." is false.
Carbamazepine reduces sodium currents, and has a mechanism of action which is as yet not known.  (See References)

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D) Valproic acid acts as a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Valproic acid acts as a glutamate receptor antagonist." is false.
Valproic acid reduces sodium currents, and causes an increase of GABA-mediated currents.  (See References)

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E) Clonazepam has a mechanism of action which is as yet not known.

This answer is incorrect.


The statement, "Clonazepam has a mechanism of action which is as yet not known." is false.
Clonazepam reduces sodium currents, and causes an increase of GABA-mediated currents.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
the mechanisms of AED action
Question ID: 299569689
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/17/2006
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