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antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

Which of the following is most accurate regarding antiepileptic medications?

 
        A) Diazepam causes reduction of T-Calcium currents.
 
        B) Topiramate has no known significant drug interactions.
 
        C) Diazepam has no known significant drug interactions.
 
        D) Zonisamide has no known significant drug interactions.
 
        E) Oxcarbazepine causes reduction of sodium currents.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Diazepam causes reduction of T-Calcium currents.

This answer is incorrect.


The statement, "Diazepam causes reduction of T-Calcium currents." is false.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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B) Topiramate has no known significant drug interactions.

This answer is incorrect.


The statement, "Topiramate has no known significant drug interactions." is false.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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C) Diazepam has no known significant drug interactions.

This answer is incorrect.


The statement, "Diazepam has no known significant drug interactions." is false.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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D) Zonisamide has no known significant drug interactions.

This answer is incorrect.


The statement, "Zonisamide has no known significant drug interactions." is false.
Zonisamide causes reduction of sodium currents, causes reduction of T-Calcium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, is approved as adjunct therapy only, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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E) Oxcarbazepine causes reduction of sodium currents.

This answer is correct.


The statement, "Oxcarbazepine causes reduction of sodium currents." is true.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
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