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antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

Which of the following statements regarding antiepileptic medications is FALSE?

 
        A) Valproic acid induces hepatic enzymes.
 
        B) Topiramate is metabolized primarily by the kidney.
 
        C) Felbamate is indicated for treatment of Lennox-Gastaut syndrome.
 
        D) Ethosuximide causes reduction of T-Calcium currents.
 
        E) Ethosuximide has leukopenia as a relatively common side effect.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Valproic acid induces hepatic enzymes.

This answer is correct.


The statement, "Valproic acid induces hepatic enzymes." is false.
Valproic acid causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatement of complex partial seizures, is indicated for tonic-clonic, is indicated for treatment of absence seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, and is excreted in breast milk.  (See References)

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B) Topiramate is metabolized primarily by the kidney.

This answer is incorrect.


The statement, "Topiramate is metabolized primarily by the kidney." is true.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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C) Felbamate is indicated for treatment of Lennox-Gastaut syndrome.

This answer is incorrect.


The statement, "Felbamate is indicated for treatment of Lennox-Gastaut syndrome." is true.
Felbamate is indicated for treatment of Lennox-Gastaut syndrome.  (See References)

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D) Ethosuximide causes reduction of T-Calcium currents.

This answer is incorrect.


The statement, "Ethosuximide causes reduction of T-Calcium currents." is true.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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E) Ethosuximide has leukopenia as a relatively common side effect.

This answer is incorrect.


The statement, "Ethosuximide has leukopenia as a relatively common side effect." is true.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
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