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antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

Which of the following statements regarding antiepileptic medications is FALSE?

 
        A) Phenobarbital is indicated for tonic-clonic.
 
        B) Gabapentin induces hepatic enzymes.
 
        C) Lamotrigine is excreted in breast milk.
 
        D) Levetiracetam has no known significant drug interactions.
 
        E) Clonazepam causes reduction of sodium currents.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Phenobarbital is indicated for tonic-clonic.

This answer is incorrect.


The statement, "Phenobarbital is indicated for tonic-clonic." is true.
Phenobarbital causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is excreted in breast milk, and can be given as a loading dose.  (See References)

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B) Gabapentin induces hepatic enzymes.

This answer is correct.


The statement, "Gabapentin induces hepatic enzymes." is false.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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C) Lamotrigine is excreted in breast milk.

This answer is incorrect.


The statement, "Lamotrigine is excreted in breast milk." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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D) Levetiracetam has no known significant drug interactions.

This answer is incorrect.


The statement, "Levetiracetam has no known significant drug interactions." is true.
Levetiracetam works via an unknown mechanism, is indicated for treatment of partial seizures, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, has no known significant drug interactions, and has no known significant interactions with other AEDs.  (See References)

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E) Clonazepam causes reduction of sodium currents.

This answer is incorrect.


The statement, "Clonazepam causes reduction of sodium currents." is true.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
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