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antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

Which of the following is most accurate regarding antiepileptic medications?

 
        A) Oxcarbazepine has no known significant drug interactions.
 
        B) Carbamazepine is metabolized primarily by the kidney.
 
        C) Clonazepam is indicated for treatment of atypical absence seizures.
 
        D) Topiramate is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 
        E) Zonisamide is the drug of first choice for patients with absence seizures only.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Oxcarbazepine has no known significant drug interactions.

This answer is incorrect.


The statement, "Oxcarbazepine has no known significant drug interactions." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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B) Carbamazepine is metabolized primarily by the kidney.

This answer is incorrect.


The statement, "Carbamazepine is metabolized primarily by the kidney." is false.
Carbamazepine causes reduction of sodium currents, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, is excreted in breast milk, must be started at a low dose, may exacerbate absence seizures, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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C) Clonazepam is indicated for treatment of atypical absence seizures.

This answer is correct.


The statement, "Clonazepam is indicated for treatment of atypical absence seizures." is true.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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D) Topiramate is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.


The statement, "Topiramate is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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E) Zonisamide is the drug of first choice for patients with absence seizures only.

This answer is incorrect.


The statement, "Zonisamide is the drug of first choice for patients with absence seizures only." is false.
Zonisamide causes reduction of sodium currents, causes reduction of T-Calcium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, is approved as adjunct therapy only, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
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