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antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

Which of the following statements regarding antiepileptic medications is FALSE?

 
        A) Oxcarbazepine is the drug of first choice for patients with absence seizures only.
 
        B) Diazepam is a known teratogen, or evidence for its teratogenicity exists.
 
        C) Topiramate is metabolized primarily by the kidney.
 
        D) Topiramate causes reduction of sodium currents.
 
        E) Phenytoin is indicated for tonic-clonic.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Oxcarbazepine is the drug of first choice for patients with absence seizures only.

This answer is correct.


The statement, "Oxcarbazepine is the drug of first choice for patients with absence seizures only." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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B) Diazepam is a known teratogen, or evidence for its teratogenicity exists.

This answer is incorrect.


The statement, "Diazepam is a known teratogen, or evidence for its teratogenicity exists." is true.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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C) Topiramate is metabolized primarily by the kidney.

This answer is incorrect.


The statement, "Topiramate is metabolized primarily by the kidney." is true.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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D) Topiramate causes reduction of sodium currents.

This answer is incorrect.


The statement, "Topiramate causes reduction of sodium currents." is true.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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E) Phenytoin is indicated for tonic-clonic.

This answer is incorrect.


The statement, "Phenytoin is indicated for tonic-clonic." is true.
Phenytoin causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is excreted in breast milk, can be given as a loading dose, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
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