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antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

Which of the following is most accurate regarding antiepileptic medications?

 
        A) Phenobarbital is associated with an increased risk of spina bifida if taken during pregnancy.
 
        B) Primidone is indicated for tonic-clonic.
 
        C) Diazepam has been shown in comparative studies to be one of the two safest of the older AEDs.
 
        D) Clonazepam is a glutamate receptor antagonist.
 
        E) Diazepam has no known significant drug interactions.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Phenobarbital is associated with an increased risk of spina bifida if taken during pregnancy.

This answer is incorrect.


The statement, "Phenobarbital is associated with an increased risk of spina bifida if taken during pregnancy." is false.
Phenobarbital causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is excreted in breast milk, and can be given as a loading dose.  (See References)

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B) Primidone is indicated for tonic-clonic.

This answer is correct.


The statement, "Primidone is indicated for tonic-clonic." is true.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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C) Diazepam has been shown in comparative studies to be one of the two safest of the older AEDs.

This answer is incorrect.


The statement, "Diazepam has been shown in comparative studies to be one of the two safest of the older AEDs." is false.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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D) Clonazepam is a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Clonazepam is a glutamate receptor antagonist." is false.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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E) Diazepam has no known significant drug interactions.

This answer is incorrect.


The statement, "Diazepam has no known significant drug interactions." is false.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
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