antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Zonisamide is indicated for treatment of partial seizures.
 
        B) Zonisamide is metabolized primarily by the kidney.
 
        C) Gabapentin can be given as a loading dose.
 
        D) Ethosuximide is indicated for treatment of myoclonic seizures.
 
        E) Primidone is approved as adjunct therapy only.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Zonisamide is indicated for treatment of partial seizures.

This answer is correct.

The statement, "Zonisamide is indicated for treatment of partial seizures." is true.
Zonisamide causes reduction of sodium currents, causes reduction of T-Calcium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, is approved as adjunct therapy only, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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B) Zonisamide is metabolized primarily by the kidney.

This answer is incorrect.

The statement, "Zonisamide is metabolized primarily by the kidney." is false.
Zonisamide causes reduction of sodium currents, causes reduction of T-Calcium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, is approved as adjunct therapy only, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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C) Gabapentin can be given as a loading dose.

This answer is incorrect.

The statement, "Gabapentin can be given as a loading dose." is false.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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D) Ethosuximide is indicated for treatment of myoclonic seizures.

This answer is incorrect.

The statement, "Ethosuximide is indicated for treatment of myoclonic seizures." is false.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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E) Primidone is approved as adjunct therapy only.

This answer is incorrect.

The statement, "Primidone is approved as adjunct therapy only." is false.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0