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Loss of the Blanket!

Topic: Physiology

Created on Monday, October 27 2008 by rednucleus

Last modified on Monday, October 27 2008.

You are investigating a young female with a suspected multiple sclerosis (MS), and CSF analysis is one of your lab tests. Your intern suggests looking for an elevated level of CSF myelin basic protein (MBP). How would you respond to him?

 
        A) Myelin basic protein is highly specific for MS
 
        B) Myelin basic protein is a useful marker of disease activity in MS patients
 
        C) CSF myelin basic protein is elevated in 95% of MS cases
 
        D) Myelin basic protein does can not be detected in blood
 
        E) CSF myelin basic protein has a limited diagnostic usefulness in neurological diseases
 

 


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This question was created on October 27, 2008 by rednucleus.
This question was last modified on October 27, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Myelin basic protein is highly specific for MS

This answer is incorrect.


Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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B) Myelin basic protein is a useful marker of disease activity in MS patients

This answer is incorrect.


Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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C) CSF myelin basic protein is elevated in 95% of MS cases

This answer is incorrect.


Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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D) Myelin basic protein does can not be detected in blood

This answer is incorrect.


Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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E) CSF myelin basic protein has a limited diagnostic usefulness in neurological diseases

This answer is correct.


Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS. CSF myelin basic protein has a limited diagnostic usefulness in neurological diseases as it can elevated in MS, strokes, head trauma, CNS infections, dementias, polyradiculopathies, brain tumors, and leukodystrophies.  (See References)

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References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York. (ISBN:0070674973)Advertising:
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physiology
Loss of the Blanket!
Question ID: 102708093
Question written by rednucleus. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 10/27/2008
Modified: 10/27/2008
Estimated Permutations: 120

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