Loss of the Blanket!

Topic: Physiology

Created on Monday, October 27 2008 by rednucleus

Last modified on Monday, October 27 2008.

 
        A) CSF myelin basic protein is elevated in 95% of MS cases
 
        B) Myelin basic protein is a useful marker of disease activity in MS patients
 
        C) CSF myelin basic protein has a limited diagnostic usefulness in neurological diseases
 
        D) Myelin basic protein does can not be detected in blood
 
        E) Myelin basic protein is highly specific for MS
 

 

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This question was created on October 27, 2008 by rednucleus.
This question was last modified on October 27, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) CSF myelin basic protein is elevated in 95% of MS cases

This answer is incorrect.

Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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B) Myelin basic protein is a useful marker of disease activity in MS patients

This answer is incorrect.

Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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C) CSF myelin basic protein has a limited diagnostic usefulness in neurological diseases

This answer is correct.

Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS. CSF myelin basic protein has a limited diagnostic usefulness in neurological diseases as it can elevated in MS, strokes, head trauma, CNS infections, dementias, polyradiculopathies, brain tumors, and leukodystrophies.  (See References)

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D) Myelin basic protein does can not be detected in blood

This answer is incorrect.

Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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---

E) Myelin basic protein is highly specific for MS

This answer is incorrect.

Myelin basic protein (MBP) is a product of oligodendroglial cells. Whenever a disease insults the CSN, this protein appears in the CSF (and even in blood and urine!). Its normal CSF level never exceeds 0.4 mg/dl. Its use in MS has declined, as it is neither specific for the disease nor it reflects disease activity. It is elevated in only 20% of clinically definite MS.  (See References)

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References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York. (ISBN:0070674973)

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physiology
Loss of the Blanket!
Question ID: 102708093
Question written by rednucleus. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 10/27/2008
Modified: 10/27/2008
Estimated Permutations: 120