antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Oxcarbazepine causes reduction of T-Calcium currents.
 
        B) Gabapentin is a glutamate receptor antagonist.
 
        C) Topiramate is metabolized primarily by the kidney.
 
        D) Gabapentin is approved as adjunct therapy only.
 
        E) Diazepam causes increase of GABA-mediated currents.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Oxcarbazepine causes reduction of T-Calcium currents.

This answer is correct.

The statement, "Oxcarbazepine causes reduction of T-Calcium currents." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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B) Gabapentin is a glutamate receptor antagonist.

This answer is incorrect.

The statement, "Gabapentin is a glutamate receptor antagonist." is true.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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C) Topiramate is metabolized primarily by the kidney.

This answer is incorrect.

The statement, "Topiramate is metabolized primarily by the kidney." is true.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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D) Gabapentin is approved as adjunct therapy only.

This answer is incorrect.

The statement, "Gabapentin is approved as adjunct therapy only." is true.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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E) Diazepam causes increase of GABA-mediated currents.

This answer is incorrect.

The statement, "Diazepam causes increase of GABA-mediated currents." is true.
Diazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is metabolized primarily in the liver, is approved as adjunct therapy only, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0