antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Topiramate works via an unknown mechanism.
 
        B) Ethosuximide causes reduction of T-Calcium currents.
 
        C) Levetiracetam works via an unknown mechanism.
 
        D) Lamotrigine is indicated for tonic-clonic.
 
        E) Topiramate induces hepatic enzymes.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Topiramate works via an unknown mechanism.

This answer is incorrect.

The statement, "Topiramate works via an unknown mechanism." is true.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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B) Ethosuximide causes reduction of T-Calcium currents.

This answer is incorrect.

The statement, "Ethosuximide causes reduction of T-Calcium currents." is true.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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C) Levetiracetam works via an unknown mechanism.

This answer is incorrect.

The statement, "Levetiracetam works via an unknown mechanism." is true.
Levetiracetam works via an unknown mechanism, is indicated for treatment of partial seizures, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, has no known significant drug interactions, and has no known significant interactions with other AEDs.  (See References)

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D) Lamotrigine is indicated for tonic-clonic.

This answer is incorrect.

The statement, "Lamotrigine is indicated for tonic-clonic." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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E) Topiramate induces hepatic enzymes.

This answer is correct.

The statement, "Topiramate induces hepatic enzymes." is false.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0