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Inclusionology 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

This intracytoplasmic inclusion may be seen in all of the following diseases, EXCEPT:

 
        A) Corticobasal degeneration
 
        B) Progressive supranuclear palsy
 
        C) Multiple system atrophy
 
        D) Frontotemporal degeneration
 
        E) Alzheimer disease
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Corticobasal degeneration

This answer is incorrect.


Originally named "corticobasal bodies", NFTs are commonly seen in brainstem nuclei in CBD  (See References)

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B) Progressive supranuclear palsy

This answer is incorrect.


NFTs generally seen in subthalamic, pallidal,dentate, nigra, LC, and nucleus basalis of Meynert (pictured here)  (See References)

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C) Multiple system atrophy

This answer is correct.


MSA is characterised by synuclein-positive inclusions within glial cells  (See References)

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D) Frontotemporal degeneration

This answer is incorrect.


Tau-associated FTD is characterised by NFTs, often in the absence of amyloid  (See References)

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E) Alzheimer disease

This answer is incorrect.


The distribution of NFTs is the basis for Braak staging of AD  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
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pathology
Inclusionology 02
Question ID: 020809085
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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