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Myelin 01

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

The brown staining cells in this active demyelinating plaque are?

 
        A) Axons
 
        B) Lymphocytes
 
        C) Astrocytes
 
        D) Macrophages
 
        E) Oligodendroglial cells
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Axons

This answer is incorrect.


Though relatively preserved in acute demyelinating lesions, axons are long and thin. They may be elucidated by silver histochemistry or neurofilament immunohistochemistry  (See References)

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B) Lymphocytes

This answer is incorrect.


Lymphocytes are seen predominantly in perivascular locations, and react with leukocyte common antigen, but not with CD68 antibodies.  (See References)

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C) Astrocytes

This answer is incorrect.


Reactive astrocytes are scattered within active demyelinating plaques, but demonstrate typical glial morphology with fibrillary processes  (See References)

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D) Macrophages

This answer is correct.


Macrophages are the primary effector cells of autoimmune demyelination, and are labelled by CD68 antibodies.  (See References)

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E) Oligodendroglial cells

This answer is incorrect.


Though it is now believed that oligodendroglial precursors persist within demyelinating lesions, they are inconspicuous, and not easily detected even with immunostaining  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
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pathology
Myelin 01
Question ID: 020809101
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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