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Neurodegen 09

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.


Courtesy of Dr. Mark Cohen
These cytoplasmic inclusions would be expected to react with all of the following, EXCEPT:

 
        A) King's silver stain
 
        B) Ubiquitin
 
        C) Paired helical filament Tau protein
 
        D) Alpha-synuclein
 
        E) Modified Bielshowsky silver stain
 

 


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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) King's silver stain

This answer is incorrect.


All silver based staining methods stain Pick bodies to a greater or lesser degree. Lewy bodies would be silver-negative.  (See References)

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B) Ubiquitin

This answer is incorrect.


Abnormal cytoskeletal proteins are conjugated to ubiquitin  (See References)

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C) Paired helical filament Tau protein

This answer is incorrect.


Major protein constituent of Pick bodies  (See References)

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D) alpha-synuclein

This answer is correct.


The size, morphology, and H&E staining characteristics of the intracytoplasmic inclusions are those of Pick bodies, not Lewy bodies  (See References)

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E) Modified Bielshowsky silver stain

This answer is incorrect.


The classical way in which Pick bodies were distinguished from Lewy bodies  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)Advertising:
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pathology
Neurodegen 09
Question ID: 021609189
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120

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