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Myasthenia Gravis 01

Topic: Pharmacology

Created on Saturday, January 10 2009 by jdmiles

Last modified on Saturday, January 10 2009.

Can a medication cause myasthenia gravis in a patient who does not have myasthenia gravis?

 
        A) No.
 
        B) Yes. Botlulinum toxin can do that.
 
        C) Yep. Pyridostigmine can do that.
 
        D) Yes. Prednisone can do that.
 
        E) You betcha. Penicillamine can do that.
 

 


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This question was created on January 10, 2009 by jdmiles.
This question was last modified on January 10, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) No.

This answer is incorrect.


Penicillamine can induce a variant of myasthenia gravis.  (See References)

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B) Yes. Botlulinum toxin can do that.

This answer is incorrect.


Botulinum toxin blocks neuromuscular junction function presynaptically. This is not the same as inducing myasthenia gravis in a patient.  (See References)

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C) Yep. Pyridostigmine can do that.

This answer is incorrect.


Pyridostigmine is an acetylcholine esterase inhibitor. It is used for symptomatic treatment of myasthenia gravis.  (See References)

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D) Yes. Prednisone can do that.

This answer is incorrect.


Prednisone can cause acute worsening of myasthenia gravis in a patient who already has myasthenia gravis. This is not the same as inducing myasthenia gravis in a patient who does not have the disease.  (See References)

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E) You betcha. Penicillamine can do that.

This answer is correct.


Penicillamine can induce a variant of myasthenia gravis.  (See References)

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References:

1. Wittbrodt, E.T. (1997). "Drugs and myasthenia gravis. An update." Arch Intern Med, 157(4) 399-408. (PMID:9046891)
2. Albers, J.W., Hodach, R.J., Kimmel, D.W., and Treacy, W.L. (1980). "Penicillamine-associated myasthenia gravis." Neurology, 30(11) 1246-9. (PMID:6252512)
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pharmacology
Myasthenia Gravis 01
Question ID: 011009133
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 01/10/2009
Modified: 01/10/2009
Estimated Permutations: 120

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