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Antiepileptic Medications 03

Topic: Pharmacology

Created on Friday, September 28 2007 by jdmiles

Last modified on Friday, September 28 2007.

Which of the following antiepileptic medications is effective in the treatment of Lennox-Gastaut syndrome, but is associated with a relatively high risk for hepatotoxicity and aplastic anemia?


 
        A) Fosphenytoin
 
        B) Ethosuximide
 
        C) Zonisamide
 
        D) Felbamate
 
        E) Topiramate
 

 


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This question was created on September 28, 2007 by jdmiles.
This question was last modified on September 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Fosphenytoin

This answer is incorrect.


Fosphenytoin is not associated with a high risk of aplastic anemia and hepatotoxicity.  (See References)

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B) Ethosuximide

This answer is incorrect.


Ethosuximide is effective in treating uncomplicated absence seizures.  It is not effective in treating motor seizures which can accompany absence seizures.  The most common serious adverse reaction is leukopenia.  Aplastic anemia can occur rarely.  It is not associated with a high risk of hepatotoxicity.  (See References)

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C) Zonisamide

This answer is incorrect.


Zonisamide is not associated with a high risk of aplastic anemia and hepatotoxicity.  (See References)

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D) Felbamate

This answer is correct.


Felbamate is considered effective as adjunctive therapy in the treatment of Lennox-Gastaut syndrome.  However, it is associated with a relatively high risk for hepatotoxicity and aplastic anemia.

  (See References)

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E) Topiramate

This answer is incorrect.


Topiramate is not associated with a high risk of aplastic anemia and hepatotoxicity.

  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
2. Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
3. Ilo E. Leppik, . . Handbooks in Health Care Company (ISBN:1931981574) Advertising:
4. French, J., Smith, M., Faught, E., and Brown, L. (1999). "Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society." Neurology, 52(8) 1540-5. (PMID:10331676)
5. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.
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pharmacology
Antiepileptic Medications 03
Question ID: 092807072
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/28/2007
Modified: 09/28/2007
Estimated Permutations: 163800

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