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Antiepileptic Medications 03

Topic: Pharmacology

Created on Friday, September 28 2007 by jdmiles

Last modified on Friday, September 28 2007.

Which of the following antiepileptic medications is effective in the treatment of Lennox-Gastaut syndrome, but is associated with a relatively high risk for hepatotoxicity and aplastic anemia?


 
        A) Valproic acid
 
        B) Felbamate
 
        C) Lamotrigine
 
        D) Phenobarbital
 
        E) Carbamazepine
 

 


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This question was created on September 28, 2007 by jdmiles.
This question was last modified on September 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Valproic acid

This answer is incorrect.


Valproic acid is used in the treatment of Lennox-Gastaut syndrome.  It can be associated with hepatotoxicity in young patients.  However, felbamate is more commonly associated wtih hepatotoxicity and aplastic anemia.  (See References)

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B) Felbamate

This answer is correct.


Felbamate is considered effective as adjunctive therapy in the treatment of Lennox-Gastaut syndrome.  However, it is associated with a relatively high risk for hepatotoxicity and aplastic anemia.

  (See References)

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C) Lamotrigine

This answer is incorrect.


Lamotrigine is approved as adjunct therapy in the treatment of Lennox-Gastaut syndrome.  It is not associated with a high risk of aplastic anemia and hepatotoxicity.   (See References)

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D) Phenobarbital

This answer is incorrect.


Phenobarbital is not associated with a high risk of aplastic anemia and hepatotoxicity.

  (See References)

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E) Carbamazepine

This answer is incorrect.


Carbamazepine is not associated with a high risk of aplastic anemia and hepatotoxicity.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
2. Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
3. Ilo E. Leppik, . . Handbooks in Health Care Company (ISBN:1931981574) Advertising:
4. French, J., Smith, M., Faught, E., and Brown, L. (1999). "Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society." Neurology, 52(8) 1540-5. (PMID:10331676)
5. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.
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pharmacology
Antiepileptic Medications 03
Question ID: 092807072
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/28/2007
Modified: 09/28/2007
Estimated Permutations: 163800

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