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Antiepileptic Medications 04

Topic: Pharmacology

Created on Friday, September 28 2007 by jdmiles

Last modified on Friday, September 28 2007.

Autoinduction is a significant issue for which of the following antiepileptic medications?


 
        A) Carbamazepine
 
        B) Levetiracetam
 
        C) Phenobarbital
 
        D) Topiramate
 
        E) Ethosuximide
 

 


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This question was created on September 28, 2007 by jdmiles.
This question was last modified on September 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Carbamazepine

This answer is correct.


Autoinduction is important to consider when dosing Carbamazepine.  The dosage required to maintain a therapeutic level in the first few weeks may change significantly after 1-2 months of treatment, when liver metabolism has been induced by the presence of Carbamazepine.

  (See References)

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B) Levetiracetam

This answer is incorrect.


Autoinduction does not occur to a clinically relevant degree with levetiracetam.  (See References)

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C) Phenobarbital

This answer is incorrect.


Autoinduction does not occur to a clinically relevant degree with phenobarbital.

  (See References)

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D) Topiramate

This answer is incorrect.


Autoinduction does not occur to a clinically relevant degree with topiramate.

  (See References)

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E) Ethosuximide

This answer is incorrect.


Autoinduction does not occur to a clinically relevant degree with ethosuximide.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
2. Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
3. Ilo E. Leppik, . . Handbooks in Health Care Company (ISBN:1931981574)Advertising:
4. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.
5. McLean, M.J. (2004). Principles of neuropharmacology and therapeutics. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 877-920.
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pharmacology
Antiepileptic Medications 04
Question ID: 092807076
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/28/2007
Modified: 09/28/2007
Estimated Permutations: 163800

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