Have you seen the parietal watch?

Tomaculae

Topic: Physiology

Created on Friday, September 19 2008 by jdmiles

Last modified on Friday, September 19 2008.

Tomaculae are characteristic of which of the following disorders?

 
        A) Tay-Sachs disease
 
        B) Diabetic neuropathy
 
        C) Hereditary neuropathy with liability to pressure palsy
 
        D) Inclusion body myositis
 
        E) Charcot-Marie-Tooth type 1
 

 


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This question was created on September 19, 2008 by jdmiles.
This question was last modified on September 19, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Tay-Sachs disease

This answer is incorrect.


Tomaculae are not a characteristic feature of Tay Sachs disease  (See References)

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B) Diabetic neuropathy

This answer is incorrect.


Tomaculae are not a characteristic feature of diabetic neuropathy  (See References)

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C) Hereditary neuropathy with liability to pressure palsy

This answer is correct.


Hereditary neuropathy with liability to pressure palsy (HNPP) is a genetic disorder resulting in neuropathy and a tendency to develop peripheral mononeuropathies. On microscopic examination of axons from people with HNPP, tomaculae (sausage-like bulges of myelin) are a typical finding.  (See References)

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D) Inclusion body myositis

This answer is incorrect.


Tomaculae are not a characteristic feature of inclusion body myositis  (See References)

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E) Charcot-Marie-Tooth type 1

This answer is incorrect.


Onion bulbs are a more characteristic feature of Charcot-Marie-Tooth type 1 than tomaculae  (See References)

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References:

1. Horowitz, S.H., Spollen, L.E., and Yu, W. (2004). "Hereditary neuropathy with liability to pressure palsy: fulminant development with axonal loss during military training." J Neurol Neurosurg Psychiatry, 75(11) 1629-31. (PMID:15489403)
2. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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physiology
Tomaculae
Question ID: 091908209
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/19/2008
Modified: 09/19/2008
Estimated Permutations: 600

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