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Methotrexate neurotoxicity, H&E stain section, high power

Last updated on Tuesday, March 24 2009 by gliageek

Methotrexate neurotoxicity, H&E stain section, high power

Necrotizing leukoencephalopathy with prominent axonal spheroids

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Methotrexate neurotoxicity, H&E stain section, high power with arrow

Methotrexate neurotoxicity, H&E stain section, high power with arrow
Axonal spheroids are a non-specific marker of axonal damage. Proximal to the point where an axon has been damaged, the cell body and proximal axon are still functioning, and axonal transport mechanisms are still trying to move molecules and organelles toward the distal end of the neuron...

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