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Glioblastoma multiforme, small cell variant, H&E stain x 200

Last updated on Friday, April 3 2009 by gliageek

Glioblastoma multiforme, small cell variant, H&E stain x 200

Glioblastomas composed predominantly of small undifferentiated glial elements must be distinguished from anaplastic oligodendrogliomas. The presence of necrosis with peripheral palisading of tumor cells is very useful in this regard. Small cell glioblastoma is often demonstrate EGFR amplification.

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Glioblastoma multiforme, small cell variant, H&E stain x 200 with arrow

Glioblastoma multiforme, small cell variant, H&E stain x 200 with arrow
One area of pseudopallisading necrosis is indicated by the unnececessarily large green arrow (arrow points to the necrotic center). Can you find the second area of pseudopallisading necrosis in this image

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