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Silver Stain - Senile Plaque

Last updated on Wednesday, April 15 2009 by gliageek

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Silver Stain - Senile Plaque
This image, from the National Institute of Aging, shows a senile plaque (dark blob in the center). The stain is a silver stain. During the 20th century, a variety of silver based histochemical techniques were developed to elucidate pathologic features not appreciable on routine H&E staining. Due to the cost of reagents, as well as technical expertise required to perform these stains, they have largely been replaced by panels of immunohistochemical stains.


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