Myelin 01

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.

 
        A) Axons
 
        B) Astrocytes
 
        C) Lymphocytes
 
        D) Macrophages
 
        E) Oligodendroglial cells
 

 

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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Axons

This answer is incorrect.

Though relatively preserved in acute demyelinating lesions, axons are long and thin. They may be elucidated by silver histochemistry or neurofilament immunohistochemistry  (See References)

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B) Astrocytes

This answer is incorrect.

Reactive astrocytes are scattered within active demyelinating plaques, but demonstrate typical glial morphology with fibrillary processes  (See References)

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C) Lymphocytes

This answer is incorrect.

Lymphocytes are seen predominantly in perivascular locations, and react with leukocyte common antigen, but not with CD68 antibodies.  (See References)

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D) Macrophages

This answer is correct.

Macrophages are the primary effector cells of autoimmune demyelination, and are labelled by CD68 antibodies.  (See References)

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E) Oligodendroglial cells

This answer is incorrect.

Though it is now believed that oligodendroglial precursors persist within demyelinating lesions, they are inconspicuous, and not easily detected even with immunostaining  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)

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pathology
Myelin 01
Question ID: 020809101
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120