Myelin 06

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.

 
        A) Megalencephaly in early stages of disease
 
        B) Peripheral neuropathy
 
        C) Mutations in astrocyte specific proteins
 
        D) Vacuolation of white matter
 
        E) Presence of metabolic astrocytosis
 

 

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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Megalencephaly in early stages of disease

This answer is correct.

Megalencephaly is seen early in the course of Canavan and Alexander disease.  (See References)

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B) Peripheral neuropathy

This answer is incorrect.

Peripheral neuropathy is not seen in either Alexander or Canavan disease  (See References)

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C) Mutations in astrocyte specific proteins

This answer is incorrect.

True of Alexander disease (GFAP) but not Canavan disease (aspartoacylase deficiency)  (See References)

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D) Vacuolation of white matter

This answer is incorrect.

Characteristic of Canavan disease, not part of Alexander disease  (See References)

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E) Presence of metabolic astrocytosis

This answer is incorrect.

Both Alzheimer type I and II astrocytes may be seen in Canavan disease, but are not part of Alexander disease  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Myelin 06
Question ID: 021509099
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120