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Neurocutaneous 07

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.

Courtesy of Dr. Mark Cohen

This tumor was removed from the cerebellum of a 26 year old woman. There is no family history of similar problems. The most cost effective next step in her evaluation would be?

A) Abdominal MRI for renal cell carcinoma

B) Careful clinical examination for epididymal cysts

C) Ophthalmological screening for retinal angiomatosis

D) Hearing test for endolymphatic sac tumor

E) Urine chemistries for pheochromocytoma

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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

ANSWERS AND EXPLANATIONS

A) Abdominal MRI for renal cell carcinoma

This answer is incorrect.

RCC develops at average age of ~40 years in vHLD (See References)


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B) Careful clinical examination for epididymal cysts

This answer is incorrect.

I wouldn't attempt this in a woman (See References)


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C) Ophthalmological screening for retinal angiomatosis

This answer is correct.

Retinal lesions are usually the first to develop in vHLD (See References)


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D) Hearing test for endolymphatic sac tumor

This answer is incorrect.

Although these also occur early in the course of vHLD, the only occur in ~10 of patients (See References)


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E) Urine chemistries for pheochromocytoma

This answer is incorrect.

Pheochromoctomas are seen in 10-20% of vHLD, with an average age of detection of 30 years old (See References)


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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Neurocutaneous 07
Question ID: 021609126
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120