Kennedy's Disease

Topic: Adult

Created on Saturday, February 24 2007 by blondarb

Last modified on Saturday, February 24 2007.

 
        A) Found on Chromosone 13p23
 
        B) GTC trinucleotide repeats
 
        C) Autosomal recessive
 
        D) Autosomal dominant
 
        E) X-linked
 

 

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This question was created on February 24, 2007 by blondarb.
This question was last modified on February 24, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Found on Chromosone 13p23

This answer is incorrect.

X-linked disorder  (See References)

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B) GTC trinucleotide repeats

This answer is incorrect.

Kennedy's disease is an x-linked disorder of trinucleotide CAG repeats. Clinically it is associated with gynecomastia, testicular atrophy and bulbar atrophy. Onset is variable but usually between the ages of 20-40.  (See References)

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C) Autosomal recessive

This answer is incorrect.

Kennedy's disease is an x-linked disorder of trinucleotide CAG repeats. Clinically it is associated with gynecomastia, testicular atrophy and bulbar atrophy. Onset is variable but usually between the ages of 20-40.  (See References)

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D) Autosomal dominant

This answer is incorrect.

Kennedy's disease is an x-linked disorder of trinucleotide CAG repeats. Clinically it is associated with gynecomastia, testicular atrophy and bulbar atrophy. Onset is variable but usually between the ages of 20-40.  (See References)

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E) X-linked

This answer is correct.

Kennedy's disease is an x-linked disorder of trinucleotide CAG repeats. Clinically it is associated with gynecomastia, testicular atrophy and bulbar atrophy. Onset is variable but usually between the ages of 20-40.  (See References)

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References:

1. http://www.ninds.nih.gov/disorders/kennedys/kennedys.htm
2. Kennedy WR, Alter M, Sung JH. Progressive proximal spinal and bulbar muscular atrophy of late onset: a sex-linked recessive trait. Neurology 1968;18:671-680. PMID 4233749.
3. La Spada A, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991;352:77-79.
4. Fischbeck KH, Lieberman A, Bailey CK, Abel A, Merry DE. Androgen receptor mutation in Kennedy's disease. Phil Trans R Soc Lond B 1999;354:1075-1078

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adult
Kennedy's Disease
Question ID: 022407170
Question written by blondarb. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/24/2007
Modified: 02/24/2007
Estimated Permutations: 7200