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An Oligo...!

Topic: Physiology

Created on Monday, October 27 2008 by rednucleus

Last modified on Monday, October 27 2008.

You are discussing the implications of CSF oligoclonal bands in various disease states and your colleague is referring to a disease that results in almost 100% detection of CSF oligoclonal bands. Which disease does your colleague mean?

A) Behjet's disease

B) Multiple sclerosis (MS)

C) Neurosyphilis

D) Subacute sclerosing panencephalitis (SSPE)

E) Neuro-lupus

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This question was created on October 27, 2008 by rednucleus.
This question was last modified on October 27, 2008.

ANSWERS AND EXPLANATIONS

A) Behjet's disease

This answer is incorrect.

CNS inflammatory diseases can result in oligoclonal bands, but the percentage is not that high. Other causes are neuro-sarcoidosis, Guillain-Barre, and primary CNS vasculitis. (See References)

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B) Multiple sclerosis (MS)

This answer is incorrect.

These bands are seen in 83-94% of clinically definite multiple sclerosis. Note that CSF oligoclonal bands are not pathognomonic for MS. (See References)

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C) Neurosyphilis

This answer is incorrect.

These bands are seen in around 50% of cases. Bacterial, tuberculous, spirochetal, and fungal CNS infections can produce CSF oligoclonal bands (See References)

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D) Subacute sclerosing panencephalitis (SSPE)

This answer is correct.

Oligoclonal bands can be found in almost 100% of cases of SSPE. Note that the bands are "oligo".i.e 2-5 in number and are found in the gamma region. A single band is commonly seen in CSFs of otherwise normal healthy individuals. (See References)

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E) Neuro-lupus

This answer is incorrect.

CNS inflammatory diseases can result in oligoclonal bands, but the percentage is not that high. (See References)

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References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York. (ISBN:0070674973)

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physiology
An Oligo...!
Question ID: 102708098
Question written by rednucleus. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 10/27/2008
Modified: 10/27/2008
Estimated Permutations: 120