the mechanisms of AED action

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Sunday, September 17 2006.

 
        A) Phenytoin reduces T-Calcium currents.
 
        B) Ethosuximide causes an increase of GABA-mediated currents.
 
        C) Valproic acid causes an increase of GABA-mediated currents.
 
        D) Diazepam has a mechanism of action which is as yet not known.
 
        E) Gabapentin has a mechanism of action which is as yet not known.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 17, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Phenytoin reduces T-Calcium currents.

This answer is incorrect.

The statement, "Phenytoin reduces T-Calcium currents." is false.
Phenytoin reduces sodium currents, causes an increase of GABA-mediated currents, acts as a glutamate receptor antagonist, and has a mechanism of action which is as yet not known.  (See References)

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B) Ethosuximide causes an increase of GABA-mediated currents.

This answer is incorrect.

The statement, "Ethosuximide causes an increase of GABA-mediated currents." is false.
Ethosuximide reduces T-Calcium currents.  (See References)

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C) Valproic acid causes an increase of GABA-mediated currents.

This answer is correct.

The statement, "Valproic acid causes an increase of GABA-mediated currents." is true.
Valproic acid reduces sodium currents, and causes an increase of GABA-mediated currents.  (See References)

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D) Diazepam has a mechanism of action which is as yet not known.

This answer is incorrect.

The statement, "Diazepam has a mechanism of action which is as yet not known." is false.
Diazepam reduces sodium currents, and causes an increase of GABA-mediated currents.  (See References)

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E) Gabapentin has a mechanism of action which is as yet not known.

This answer is incorrect.

The statement, "Gabapentin has a mechanism of action which is as yet not known." is false.
Gabapentin causes an increase of GABA-mediated currents, and acts as a glutamate receptor antagonist.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
the mechanisms of AED action
Question ID: 299569689
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/17/2006
Estimated Permutations: 0