Last modified on Monday, February 11 2013.
Courtesy of Dr. Mark Cohen
This section was obtained from the frontal neocortex of a patient with behavioral variant dementia. Which is the following antibodies would react most strongly with the neuronal cytoplasmic inclusion?
Alpha-synuclein is the predominant protein found within Lewy bodies, but is not identified within Pick bodies. (
Glial fibrillary acidic protein is the predominant intermediate filament within astrocytes, but is not present with in neurons. (
Although inclusions immunoreactive with TDP-43 comprise the most common pathological form of frontotemporal lobar degeneration, The protein is not found within Pick bodies. (
Inclusions immunoreactive with FUS (fused in sarcoma) are found within a subset of patients with frontotemporal lobar degeneration. These patients may demonstrate basophilic intraneuronal inclusions, but not Pick bodies. (