There are 486 questions on various topics in Neurology in the FrontalCortex neurology question bank.

Inclusionology 03

Topic: Imaging

Created on Monday, February 11 2013 by gliageek

Last modified on Monday, February 11 2013.

Courtesy of Dr. Mark Cohen

This section was obtained from the frontal neocortex of a patient with behavioral variant dementia. Which is the following antibodies would react most strongly with the neuronal cytoplasmic inclusion?

A) GFAP

B) Alpha-synuclein

C) Tau

D) FUS

E) TDP-43

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This question was created on February 11, 2013 by gliageek.
This question was last modified on February 11, 2013.

ANSWERS AND EXPLANATIONS

A) GFAP

This answer is incorrect.

Glial fibrillary acidic protein is the predominant intermediate filament within astrocytes, but is not present with in neurons. (See References)

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B) Alpha-synuclein

This answer is incorrect.

Alpha-synuclein is the predominant protein found within Lewy bodies, but is not identified within Pick bodies. (See References)

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C) Tau

This answer is correct.

Pick bodies are composed predominantly of cross-linked tau protein (See References)

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D) FUS

This answer is incorrect.

Inclusions immunoreactive with FUS (fused in sarcoma) are found within a subset of patients with frontotemporal lobar degeneration. These patients may demonstrate basophilic intraneuronal inclusions, but not Pick bodies. (See References)

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E) TDP-43

This answer is incorrect.

Although inclusions immunoreactive with TDP-43 comprise the most common pathological form of frontotemporal lobar degeneration, The protein is not found within Pick bodies. (See References)

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References:

1. Dickson, D.W., Kouri, N., Murray, M.E., and Josephs, K.A. (2011). "Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)." J Mol Neurosci, 45(3) 384-9. (PMID:21720721)

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imaging
Inclusionology 03
Question ID: 021113119
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/11/2013
Modified: 02/11/2013
Estimated Permutations: 120