Inactive demyelinated plaque, H&

This is an H&E preparation of an older, inactive demyelinated plaque from the brain of a person with MS. There is no active demyelination going on in this plaque. In this image, we see the border between the plaque (pale, indicated by the unnecessarily large red arrow) and normal neuropil (darker, indicated by the unnecessarily large green arrow). Note that, while the plaque is pale, indicating a lack of myelin, the overall structure appears very similar to that of the normal neuropil, as axons remain intact.