Krabbe disease, H&E stained sect

Another name for Krabbe disease is globoid cell leukodystrophy. The reason for this is the presence of these very large globoid cells, which are a hallmark of Krabbe disease, and which are easily seen in this H&E-stained preparation of brain from a person with Krabbe disease. The unnecessarily large green arrow points to one of several globoid cells visible in this image.