Malformations 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.

 
        A) Hemimegalencephaly
 
        B) Intrauterine ischemia
 
        C) Aicardi syndrome
 
        D) Intrauterine infection
 
        E) Doublecortin mutation
 

 

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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) hemimegalencephaly

This answer is incorrect.

PMG is often seen in association with HME, and may be prominent in patients resected for HME  (See References)

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B) intrauterine ischemia

This answer is incorrect.

The MCA distribution has suggested that intrauterine ischemia may be important in the genesis of sporadic polymicrogyria  (See References)

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C) Aicardi syndrome

This answer is incorrect.

PMG, along with subcortical heterotopias, is a prominent component of this x-linked syndrome  (See References)

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D) intrauterine infection

This answer is incorrect.

PMG has been reported in association with intrauterine CMV, VZV, toxo, and syphilis.  (See References)

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E) doublecortin mutation

This answer is correct.

Doublecortin mutations result in diffuse x-linked lissencephaly  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)

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pathology
Malformations 02
Question ID: 020809088
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120