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Malformations 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Courtesy of Dr. Mark Cohen

This appearance may be seen in all of the following conditions, EXCEPT:

 
        A) Intrauterine infection
 
        B) Aicardi syndrome
 
        C) Intrauterine ischemia
 
        D) Doublecortin mutation
 
        E) Hemimegalencephaly
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) intrauterine infection

This answer is incorrect.


PMG has been reported in association with intrauterine CMV, VZV, toxo, and syphilis.  (See References)

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B) Aicardi syndrome

This answer is incorrect.


PMG, along with subcortical heterotopias, is a prominent component of this x-linked syndrome  (See References)

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C) intrauterine ischemia

This answer is incorrect.


The MCA distribution has suggested that intrauterine ischemia may be important in the genesis of sporadic polymicrogyria  (See References)

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D) doublecortin mutation

This answer is correct.


Doublecortin mutations result in diffuse x-linked lissencephaly  (See References)

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E) hemimegalencephaly

This answer is incorrect.


PMG is often seen in association with HME, and may be prominent in patients resected for HME  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)Advertising:
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pathology
Malformations 02
Question ID: 020809088
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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