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Alexander Disease on T2-weighted MRI

Last updated on Sunday, March 29 2009 by jdmiles

Alexander Disease on T2-weighted MRI

The findings in this MRI are typical for Alexander disease. MRI criteria for the diagnosis of Alexander disease include: 1. Extensive, frontally-predominant cerebral white matter changes 2. A periventricular rim which is bright on T1 and dark on T2 3. Brainstem abnormalities 4. Abnormalities of hte basal ganglia and thalami 5. Contrast enhancement of particular gray and white matter structures. Four of 5 criteria should be met to make the diagnosis based on imaging.

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