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Glioblastoma multiforme with granular cell differentiation, intraoperative smear x 400. with arrow

Last updated on Saturday, April 4 2009 by jdmiles

Glioblastoma multiforme with granular cell differentiation, intraoperative smear x 400. with arrow

Granular differentiation and malignant astrocytic tumors may resemble macrophages on intraoperative smear preparations. Macrophages generally demonstrate more foamy cytoplasm, while granular cells demonstrate coarse eosinophilic granularity such as is seen here. The cytoplasm of a tumor cell is indicated by the unnecessarily large green arrow.

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