SEGA

Last updated on Wednesday, September 10 2008 by jdmiles

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Subependymal giant cell astrocytoma, H&E stain x 40
Subependymal giant cell astrocytomas often demonstrate prominent microcalcifications.

Subependymal giant cell astrocytoma x200
Subependymal giant cell astrocytomas demonstrate a biphasic population consisting of fibrillary astrocytic cells and epithelioid cells demonstrating homogeneous eosinophilic cytoplasm with nuclei reminiscent of ganglion cell differentiation. Note the ependymal...

Subependymal giant cell astrocytoma x400
Microcalcifications admixed with fibrillary astrocytic cells and epithelioid tumor cells of uncertain histogenesis ( by H&E morphology)

Subependymal Giant Cell Astrocytoma, GFAP immunohistochemical staining x 400
GFAP immunohistochemical staining preferentially reacts with fibrillary-appearing cellular elements within Subependymal giant cell astrocytoma.

Subependymal Giant Cell Astrocytoma, High power H&E stained section.
The 3 characteristic elements of Subependymal giant cell astrocytomas R. fibrillary astrocytic cells, epithelioid cells with normal nuclear morphology and glial appearing cytoplasm, and intratumoral microcalcifications.

Subependymal Giant Cell Astrocytoma, Neurofilament immunohistochemical staining
Epithelioid cells within Subependymal giant cell astrocytomas often react strongly with antibodies to neurofilaments. This admixture of cell types strengthens the biologic identity with tuberous sclerosis, and has lead to the suggestion that these tumors be re-named subependymoma giant cell tumors...

Subependymal Giant Cell Astrocytoma, intraoperative smear preparation x 200
Subependymal giant cell astrocytomas demonstrate a characteristic morphology on intraoperative cytologic preparations consisting of relatively monomorphic cells with abundant eosinophilic cytoplasm and neuronal nuclear morphology. Monomorphism and absence...