Primary CNS Lymphoma

Last updated on Wednesday, September 10 2008 by jdmiles

Related images:

Primary central nervous system lymphoma, H&E stain x 200
Primary central nervous system lymphomas are composed of large monomorphic B cells with large nuclei and prominent nucleoli

Primary central nervous system lymphoma, intra-operative crush preparation x 400
Discohesive monomorphic enlarged atypical cells with prominent nucleoli characterize primary CNS lymphoma on cytologic preparations

Primary central nervous system lymphoma, reticulin histochemistry x 400
Markedly increased perivascular reticulin staining is a constant feature a primary CNS lymphoma, and was responsible for its initial designation as reticulin cell sarcoma

PCNSL Smear x40
PCNSL Smear x40

Primary central nervous system lymphoma, intra-operative crush preparation x 600
Discohesive monomorphic atypical lymphoid cells with prominent nucleoli.

Primary central nervous system lymphoma, CD20 immunohistochemical staining
The overwhelming majority of primary CNS lymphomas are malignant large B-cell lymphomas positive for CD20 immunostaining.

Primary central nervous system lymphoma, high power H&E stain
Angiocentricity and angioinvasion characterize primary CNS lymphoma.

Primary CNS lymphoma, cerebral peduncle and midbrain, H&E stain x 40
Angiocentricity is nicely demonstrated in this low power view of the cerebral peduncle infiltrated by primary CNS lymphoma.

Primary CNS lymphoma, H&E stain x 400
Angiocentricity and angioinvasion by large atypical lymphocytes with prominent nucleoli. Note admixed reactive-appearing lymphocytes, which are usually composed of host T-cells.