Other Hematopoietic Tumors

Last updated on Wednesday, September 10 2008 by jdmiles

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Amyloidoma, cerebral parenchyma, H&E stain.
Plasmacytic lesions may present as mass occupying accumulations of extracellular amyloid protein composed of apparently secreted light chain immunoglobulin.

Amyloidoma, cerebral cortex, polarization microscopy after Congo red stain.
Amyloid is characterized by apple-green birefringence upon polarization of Congo red stained sections

Amyloidotic plasmacytoma, H&E stain x200
Some plasmacytic lesions are composed predominately of extracellular amyloid. This patient presented with cord compression secondary to a destructive lesion within the vertebral column.

Plasmacytoma, H&E stained slide x 400
This patient presented with spinal cord compression secondary to vertebral plasmacytoma.

Plasmacytoma, intraoperative crush preparation x 400
Discohesive lymphoplasmacytic cells, consistent with derivation from plasmacytoma.

Spine Amyloidoma
Spine Amyloidoma

Spine amyloidoma, H&E stainx 400
Admixture of amyloid and plasma cells is typical within space occupying amyloid masses

Intravascular lymphomatosis, CD20 immunohistochemical staining
This image illustrates intravascular lymphomatosis in brain. This sample is prepared with a CD-20 immune stain. The brownish staining cells are lymphoma cells which express CD20. Note that these cells remain within blood vessels.

Intravascular lymphomatosis, stereotactic biopsy, H&E stain x 400
Blood vessels are occluded and distended by a neoplastic lymphoid cells

Intravascular lymphomatosis, H&E stain x 400
Distention of intraparenchymal blood vessel by large atypical lymphocytes with prominent nucleoli.

Leptomeningeal and perivascular spread of leukemic cells in a patient with AML, H&E stain x 100
Perivascular spread into adjacent brain parenchyma in a patient with leukemic meningitis

CNS leukemia x400
CNS leukemia x400

Meningeal Leukemia x200
Meningeal Leukemia x200

Extranodal marginal zone B-cell lymphoma (MALToma) of dura mater, H&E stain x 400
Morphology is reminiscent of Peyer's patches with superimposed atypia.

Extranodal marginal zone B-cell lymphoma (MALToma) , intraoperative smear,H&E stain x 400
Unlike intraparenchymal lymphomas, which are all diffuse large B-cell lymphomas, lymphomas involving the coverings of the brain demonstrate a broader spectrum of morphologies.

Dura Malt Lymphoma x100
Dura Malt Lymphoma x100

Large B-cell Lymphoma Leg, H&E stained section
This patient developed central nervous system metastasis composed of large atypical B cells, similar to those seen within primary CNS lymphoma

Large B-cell, Burkitt-like lymphoma within brain parenchyma, H&E stained section x 200
Diffuse large B-cell lymphoma of the leg represents a rare cause of CNS metastasis by non-small cell lymphoma.

Lymphoma peripheral nerve root, 200x
Peripheral nervous system recurrence in a patient with known history of cutaneous lymphoproliferative disease.