Pediatric Brain Tumor Pathology 01

Topic: Pathology

Created on Sunday, February 24 2008 by jdmiles

Last modified on Sunday, February 24 2008.

 
        A) This tumor is classified as WHO Grade I
 
        B) This patient likely has neurofibromatosis type II
 
        C) Tumors of this type often cause hydrocephalus by obstructing the foramen of Magendie
 
        D) This patient likely has neurofibromatosis type I
 
        E) This tumor is classified as WHO Grade IV
 

 

	= Go back to the top of the page.
	= Reload a different version of this question ().
	= Load a random question from the database.
	= Use this question as a template to create a totally NEW question.
	= Enter detailed rating for this question!
	= How users like you have rated this question.

This question was created on February 24, 2008 by jdmiles.
This question was last modified on February 24, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

---

A) This tumor is classified as WHO Grade I

This answer is correct.

This tumor is a subependymal giant cell astrocytoma (SEGA). These tumors are typically long and sausagelike in appearance, often occurring in the lateral ventricle. They may cause hydrocephalus by obstructing the foramen of Munro. They are the most frequent neoplasm in children with tuberous sclerosis complex (TSC), and most SEGAs are associated with TSC. Calcification is typical. This is a slow-growing, WHO Grade I tumor. Pathologic appearance is as shown, with many astrocytes with abundant cytoplasm, often arranged in pseudorosettes. Some tumor cells may appear neuronal, and have prominent nucleoli.  (See References)

Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 

---

B) This patient likely has neurofibromatosis type II

This answer is incorrect.

This tumor is associated with tuberous sclerosis, not neurofibromatosis.  (See References)

Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 

---

C) Tumors of this type often cause hydrocephalus by obstructing the foramen of Magendie

This answer is incorrect.

This tumor does often cause hydrocephalus. However, tumors of this type typically occur in the lateral ventricle, making them more likely to occlude the foramen of Munro than the foramen of Magendie.  (See References)

Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 

---

D) This patient likely has neurofibromatosis type I

This answer is incorrect.

This tumor is associated with tuberous sclerosis, not neurofibromatosis.  (See References)

Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 

---

E) This tumor is classified as WHO Grade IV

This answer is incorrect.

This is a slow-growing, WHO Grade I tumor.  (See References)

Please log in if you want to rate questions.

 

 

 

 

References:

1. DeBiasi, R.L., Solbrig, M.V., and Tyler, K.L. (2004). Viral infections. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1515-1543 (ISBN:0750674695).	Advertising:
2. Lopes, M.B., Altermatt, H.J., Scheithauer, B.W., Shepherd, C.W., and VandenBerg, S.R. (1996). "Immunohistochemical characterization of subependymal giant cell astrocytomas." Acta Neuropathol, 91(4) 368-75. (PMID:8928613)

Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
pathology
Pediatric Brain Tumor Pathology 01
Question ID: 022408120
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/24/2008
Modified: 02/24/2008
Estimated Permutations: 60480