Periventricular Leukomalacia

Last updated on Tuesday, September 9 2008 by jdmiles

Related images:

Organizing periventricular leukomalacia, high power H&E stain
Admixture of lipidized macrophages and globoid reactive astrocytes

Periventricular leukomalacia with hemorrhagic transformation.
Note absence of evidence of intraventricular hemorrhage as well as bilateral symmetry within the subcortical and deep white matter damage

Neonatal brain, micro-injection of cerebral circulation
Note distribution of penetrating blood vessels with regard to the ventricular lining/end artery watershed

Periventricular Leukomalacia With Cavitation
Bilateral and cystic degeneration of subcortical and deep white matter structures

Periventricular leukomalaciawith advanced cavitation, right frontal lobe, coronal section.
Near total degeneration of frontal white matter.

Periventricular leukomalacia with hemorrhagic transformation
Reperfusion into a necrotic capillary bed

Periventricular white matter infarcts, Close up
Recent periventricular white matter infarcts typically manifests as chalky white spots along the subependymal region of the lateral ventricular system.

Periventricular leukomalacia, coronal
Organizing, but not yet cavitary necrosis, bilateral parietal white matter.

Periventricular leukomalacia, low-power H&E stained section
well demarcated lesion within periventricular white matter

Organizing periventricular leukomalacia
Well-circumscribed lesion containing swollen axons and lipid-laden macrophages

Periventricular leukomalacia with organized hemorrhage, Berlin blue stain for iron
Berlin blue reacts with ferric iron, and is consistent with remote/organized hemorrhage. Cholesterol clefts indicate areas of organized red cell membranes