Miscellaneous Tumors

Last updated on Wednesday, September 10 2008 by jdmiles

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Cystic hypothalamic hamartoma, gross photographs of surgically resected tumor
The solid portion of the hamartoma appears identical to cerebral gray matter, both grossly and microscopically. The presence of the cyst is unusual in these tumors. The patient presented with precocious puberty.

Sacrococcygeal Teratoma, gross photograph of Cauda Equina
Sacrococcygeal Teratoma generally presents as a congenital lesion, and tends to pursue a benign course in the absence of elements of yolk sac tumor.

Subependymoma of lateral ventricle, H&E stain x 100
Subependymomas in the lateral ventricles often demonstrate prominent microcystic change, as seen here. Ependymomal lining is at the right side of the photographed.

Meningeal melanocytosis, H&E stain x 40
Proliferation and migration of transformed pial melanocytes has resulted in marked thickening of the arachnoid.

Meningeal Melanocytosis, H&E stain x 100
Meningeal melanocytosis demonstrates a marked propensity to invade and migrate a long perivascular spaces.

Menigioangiomatosis, H&E stain x 40
Perivascular proliferation of spindle-shaped cells with entrapped non-neoplastic cerebral cortex. Patients with meningioangiomatosis usually present with childhood epilepsy. Meningioangiomatosis may also be seen asymptomatically in patients with neurofibromatosis...

Primary meningeal melanoma, H&E stained slide x 200.
Islands of tumor cells track along the perivascular spaces. Diagnosis of primary meningeal melanoma requires exclusion of extra-neural melanomas, but also obtained to demonstrate fewer mitotic figures and less coagulative tumor necrosis. In addition, a generally...

Primary Meningeal Melanoma, H&E stain x 400
Primary meningeal melanoma usually demonstrates fewer mitotic figures and less coagulative tumor necrosis than metastatic malignant melanomas.

Primary Meningeal Melanoma H&E x400
Primary Meningeal Melanoma H&E x400

Sclerotic meningioangiomatosis, H&E stain x 100.
Rarely, meningioangiomatosis may demonstrate extensive sclerosis, nearly effacing intervening brain parenchyma.

Tumoral calcinosis, H&E stain x 200
Tumoral calcinosis may present as an extradural spinal cord lesion with spinal cord compression. Most patient's did not demonstrate evidence of endocrine abnormality or hypercalcemia.

Immature Teratoma of pineal region demonstrating primitive retinal differentiation, H&E stain x 200
A indicates retinal anlage.

Immature Teratoma of pineal region, H&E stain x 40
Within a region of Glioneuronal differentiation is a focus of deeply pigmented primitive neuroectodermal cells indicative of primitive retinal differentiation. A small focus of bronchial type mucosa is present along the bottom of the photograph.

Choroid plexus papilloma, H&E stain x 400
As the name implies, the choroid plexus papilloma combines the features of a papilloma with glandular differentiation resulting in a papillary-type adenoma.

Non-neoplastic choroid plexus, H&E stain x 400
Compared with choroid plexus papilloma, normal choroid plexus demonstrates lower nucleus to cytoplasmic ratio, less hyperchromatic nuclei, and more irregular, hobnail type pattern to the luminal surface.

Chordoma (clivus), H&E stain x 100
Nodules of tumor separated by tumor filled septae

Clival chordoma, H&E stain x 400
Multi-Vacuolated cells, referred to as physaliferous cells (having the appearance of being filled with soap bubbles), are characteristically present within chordomas. However, similar cells may be seen in adenocarcinomas and/or chondrosarcomas requiring immunohistochemical distinction for diagnosis.