Vascular Disease 2: Vasculitides

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Vascular Disease 2: Vasculitides

Last updated on Sunday, July 20 2008 by jdmiles

Related images:

Primary angiitis of the central nervous system, low power H&E stained section
Vasculocentric lymphoid infiltrate involving small intraparenchymal blood vessels without evidence of parenchymal inflammation.

Primary angiitis of the central nervous system, high power H&E stained slide
Lymphoplasmacytic vascular wall inflammation. A poorly formed granuloma can be seen just to the left of center within this photograph

Giant cell arteritis involving temporal artery, high power H&E stained slide
Multi-Nucleated giant cells are present in association with external elastic lamina.

Giant Cell Arteritis, H&E stained x 100
Granulomatous segmental vascular inflammation is present in the upper left corner of the photographed, accompanied by intimal proliferation with luminal stenosis seen extending from the center the photograph to the lower right corner

Giant Cell arteritis, H&E stained slide x200
Numerous multinucleated giant cells are seen within the media of the affected medium-sized arteries

Giant Cell Arteritis, H&E stain x40
This overview of the histopathology of giant cell arteritis demonstrates predominantly medial inflammation involving most of the circumference of the artery, accompanied by a brisk intimal proliferation with luminal stenosis.

Giant Cell Arteritis, H&E stain x400
Multinucleate giant cells are present in intimate association with fragments of external elastic lamina.

Juvenile temporal arteritis with eosinophilia, medium power H&E stained slide.
Juvenile temporal arteritis with eosinophilia can be encountered in patients with Kimira disease, where the temporal artery may be fortuitously involved by one of the subcutaneous masses encountered in this disease

Juvenile temporal arteritis with eosinophilia, H&E stained section x 20
The temporal artery may be markedly involved by subcutaneous lesions of Kimura disease

Primary angiitis of the central nervous system, leptomeningeal blood vessel, high power H&E
Including leptomeningeal blood vessels increases the diagnostic yield the brain biopsy for primary angiitis of the nervous system

Primary angiitis of the nervous system, low power H&E stained section including leptomeninges
Leptomeningeal blood vessels are commonly involved in primary angiitis of the central nervous system.

Temporal Artery, Surgical Exposure
The gross appearance of the temporal artery may hint at the diagnosis, but may also be deceiving

Amyloid beta related angiitis, H. and E. stain x 400
Granulomatous angiitis associated with amyloid angiopathy comprises a distinct entity referred to as amyloid beta related angiitis (ABRA)

Amyloid beta related angiitis, H&E stained x 100
Amyloid beta related angiitis is typically encountered in an older population of patients compared with non-amyloid associated primary central nervous system angiitis.

Review of the relevant anatomy