Pathology in Alzheimer dementia 01

Topic: Pathology

Created on Saturday, April 28 2007 by jdmiles

Last modified on Saturday, April 28 2007.

 
        A) The pathologic finding in this image is intracellular
 
        B) This finding is not uncommon in cognitively normal adults
 
        C) This image shows a neurofibrillary tangle
 
        D) This pathology is pathognomonic for Alzheimer disease
 
        E) This type of pathology tends to accumulate in the brainstem
 

 

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This question was created on April 28, 2007 by jdmiles.
This question was last modified on April 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) the pathologic finding in this image is intracellular

This answer is incorrect.

The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques are extracellular accumulations of beta amyloid protein. Neurofibrillary tangles are intracellular.  (See References)

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B) this finding is not uncommon in cognitively normal adults

This answer is correct.

The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques, while associated with Alzheimer disease and other dementing processes, are also seen in the brains of adults with mild cognitive impairment, and in cognitively normal adults.  (See References)

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C) this image shows a neurofibrillary tangle

This answer is incorrect.

The slide shows an amyloid plaque (a.k.a. "senile plaque"), not a neurofibrillary tangle.  (See References)

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D) this pathology is pathognomonic for Alzheimer disease

This answer is incorrect.

The slide shows an amyloid plaque (a.k.a. "senile plaque"). Amyloid plaques, while associated with Alzheimer disease and other dementing processes, are also seen in the brains of adults with mild cognitive impairment, and in cognitively normal adults.  (See References)

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E) this type of pathology tends to accumulate in the brainstem

This answer is incorrect.

The slide shows an amyloid plaque (a.k.a. "senile plaque"). These typically accumulate in the neocortex of the brain.  (See References)

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References:

1. Morris, J.C., Storandt, M., McKeel, D.W., Rubin, E.H., Price, J.L., Grant, E.A., and Berg, L. (1996). "Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease." Neurology, 46(3) 707-19. (PMID:8618671)
2. Schmitt, F.A., Davis, D.G., Wekstein, D.R., Smith, C.D., Ashford, J.W., and Markesbery, W.R. (2000). ""Preclinical" AD revisited: neuropathology of cognitively normal older adults." Neurology, 55(3) 370-6. (PMID:10932270)
3. Bennett, D.A., Schneider, J.A., Arvanitakis, Z., Kelly, J.F., Aggarwal, N.T., Shah, R.C., and Wilson, R.S. (2006). "Neuropathology of older persons without cognitive impairment from two community-based studies." Neurology, 66(12) 1837-44. (PMID:16801647)
4. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia.

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pathology
Pathology in Alzheimer dementia 01
Question ID: 042807088
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 04/28/2007
Modified: 04/28/2007
Estimated Permutations: 3000