Pseudotumor Cerebri 02

Topic: Pharmacology

Created on Sunday, September 23 2007 by jdmiles

Last modified on Sunday, September 23 2007.

A 30 year old, right-handed obese female presents with several weeks of worsening headache and blurred vision. Papilledema is seen on funduscopic exam. Imaging of the brain, including an MRV, shows no abnormalities.

Which of the following medications that she takes is the most likely cause of her disease?

A) Levodopa + Carbidopa

B) Cocaine

C) Acetazolamide

D) Nalidixic acid

E) Fluoxetine

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This question was created on September 23, 2007 by jdmiles.
This question was last modified on September 23, 2007.

ANSWERS AND EXPLANATIONS

A) Levodopa + Carbidopa

This answer is incorrect.

This patient has pseudotumor cerebri. Levodopa/Carbidopa is not typically considered a cause of this disease.

Drugs and chemicals that are associated with pseudotumor cerebri include: Vitamin A, Tetracycline and related compounds, anabolic steroids, growth hormone, lithium, nalidixic acid, Norplant, and the insecticide chlordecone. Treatment should involve discontinuation of these agents.

(See References)


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B) Cocaine

This answer is incorrect.

This patient has pseudotumor cerebri. Cocaine is not typically considered a cause of this disease.

(See References)


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C) Acetazolamide

This answer is incorrect.

This patient has pseudotumor cerebri. Acetazolamide is not typically considered a cause of this disease.

(See References)


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D) Nalidixic acid

This answer is correct.

This patient has pseudotumor cerebri. Nalidixic acid is associated with this disease. Treatment should involve discontinuation of this medication.

The term idiopathic intracranial hypertension would not be appropriate in her case, as her medication is the likely etiology for her intracranial hypertension.

(See References)


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E) Fluoxetine

This answer is incorrect.

This patient has pseudotumor cerebri. Fluoxetine is not typically considered a cause of this disease.

(See References)


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References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York.
2. Donaldson, J.O. (1981). "Pathogenesis of pseudotumor cerebri syndromes." Neurology, 31(7) 877-80. (PMID:7195510)
3. Friedman, D.I., and Jacobson, D.M. (2002). "Diagnostic criteria for idiopathic intracranial hypertension." Neurology, 59(10) 1492-5. (PMID:12455560)


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pharmacology
Pseudotumor Cerebri 02
Question ID: 092307086
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/23/2007
Modified: 09/23/2007
Estimated Permutations: 201600