Epinephrine 01

Topic: Pharmacology

Created on Saturday, October 18 2008 by jdmiles

Last modified on Saturday, October 18 2008.

 
        A) Threonine
 
        B) Phenylalanine
 
        C) Glycine
 
        D) Arginine
 
        E) Tyrosine
 

 

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This question was created on October 18, 2008 by jdmiles.
This question was last modified on October 18, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Threonine

This answer is incorrect.

Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.
Epinephrine is synthesized from norepinephrine by phenylethanolamine-N-methyl transferase.  (See References)

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B) Phenylalanine

This answer is incorrect.

Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.
Epinephrine is synthesized from norepinephrine by phenylethanolamine-N-methyl transferase.  (See References)

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---

C) Glycine

This answer is incorrect.

Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.
Epinephrine is synthesized from norepinephrine by phenylethanolamine-N-methyl transferase.  (See References)

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---

D) Arginine

This answer is incorrect.

Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.
Epinephrine is synthesized from norepinephrine by phenylethanolamine-N-methyl transferase.  (See References)

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---

E) Tyrosine

This answer is correct.

Dopamine, epinephrine, and norepinephrine (the catecholamine neurotransmitters) are all derived from tyrosine.
The first (and rate-limiting) step in the synthesis of dopamine is the conversion of tyrosine into L-DOPA by tyrosine hydroxylase.
Then, L-DOPA is converted into Dopamine by DOPA decarboxylase.
Dopamine is converted to norepinephrine by dopamine beta-hydroxylase.
Epinephrine is synthesized from norepinephrine by phenylethanolamine-N-methyl transferase.  (See References)

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References:

1. Kandel, E.R., Schwartz, J.H., and Jessel, T.M. (2000). Principles of Neural Science, 4th ed. McGraw-Hill, New York. (ISBN:0838577016)

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pharmacology
Epinephrine 01
Question ID: 101808189
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/18/2008
Modified: 10/18/2008
Estimated Permutations: 3825360