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Toxicity and Characteristic Pathology 01

Topic: Pathology

Created on Wednesday, November 28 2007 by jdmiles

Last modified on Wednesday, November 28 2007.

A 25 year old man in previously good health is found at home, comatose and with bright red skin. After a few days in the ICU, the patient expires. Carbon monoxide poisoning is the suspected cause of death.

On autopsy, what findings in the brain can you expect to see?

A) Bilateral hippocampus lesions

B) Bilateral caudate lesions

C) Bilateral globus pallidus lesions

D) Bilateral substantia nigra lesions

E) Bilateral amygdala lesions

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This question was created on November 28, 2007 by jdmiles.
This question was last modified on November 28, 2007.

ANSWERS AND EXPLANATIONS

A) Bilateral hippocampus lesions

This answer is incorrect.

Bilateral globus pallidus lesions are a common finding in carbon monoxide poisoning.
(See References)


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B) Bilateral caudate lesions

This answer is incorrect.

Bilateral globus pallidus lesions are a common finding in carbon monoxide poisoning.
(See References)


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C) Bilateral globus pallidus lesions

This answer is correct.

Bilateral globus pallidus lesions are a common finding in carbon monoxide poisoning.
(See References)


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D) Bilateral substantia nigra lesions

This answer is incorrect.

Bilateral globus pallidus lesions are a common finding in carbon monoxide poisoning.
(See References)


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E) Bilateral amygdala lesions

This answer is incorrect.

Bilateral globus pallidus lesions are a common finding in carbon monoxide poisoning.
(See References)


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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)	Advertising:
2. Lapresle, J., and Fardeau, M. (1967). "The central nervous system and carbon monoxide poisoning. II. Anatomical study of brain lesions following intoxication with carbon monixide (22 cases)." Prog Brain Res, 24 31-74. (PMID:6075035)


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pathology
Toxicity and Characteristic Pathology 01
Question ID: 112807175
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 11/28/2007
Modified: 11/28/2007
Estimated Permutations: 600

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